I was skeptical about Melanotan. I have been on it now exactly 2 weeks (taking a dose every night) and I've already started too see my skin color changing and getting darker. Plan on doing it another full week, and see where I am from that point. The needle doesn't hurt, but I suggest if you don't want to feel any pain, just order some topical numbing cream from Amazon (Numb520) and numb the skin for about 5 min before using the alcohol swab to clean before the poke. Be prepared for your moles to get darker, and any Hyperpigmentation you have to appear more than before. Other than that, that is the only side effect I've gotten. No tingling sensation or nausea. In fact, I feel nothing after injection which is a good thing. I'm excited too see where I'll be in another week, once I reach the level of tone, i plan to do only a few doses a week for maintenance. P.S. Another tip, once you mix the solution, keep it in the fridge (I use my skin care mini fridge in my bathroom) It keeps the peptide for maximum quality.